The Giants are 3.5-point home underdogs against the Cowboys on Sunday Night Football in the latest Week 1 NFL odds. The Giants (14-5) had the best record against the spread last season, including the playoffs, but they won't be surprising many as underdogs this season. The parity is evident when looking at the Week 1 NFL odds, so who can you feel confident in? Seven of the 15 remaining Week 1 games have the favorite listed at -3 or lower in the NFL Vegas odds.

Every team wants to think its offseason moves will either help them remain toward the top or become a Cinderella, defying NFL spreads week after week. When you look at the Week 1 NFL schedule, teams are full of optimism. The 2023 NFL season is here and Week 1 can be the toughest week for oddsmakers and sports bettors looking to make their picks based on the Week 1 NFL odds.